• RESEARCH

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    Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an a nimal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network's tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically-based computational models to explore questions of gene regulatory network function. We exploit naturally-occuring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.

     

  • OPPORTUNITIES

    The Wunderlich lab is looking for enthusiastic students and post docs to join the lab.

     

    Graduate Students

    To join the lab, graduate students must apply and be accepted to of one of BU's graduate programs, e.g. the Molecular Biology, Cell Biology & Biochemistry, Biology, Bioinformatics, or BME programs. No direct admissions to the lab are possible.

     

    Postdoctoral Fellows

    Applicants interested in postdoctoral fellowship positions can send a CV and cover letter describing your previous research experience and future research interests, including why you are interested in the lab, to Zeba.

     

    Undergraduate Students

    Undergraduates interested in studies of gene regulation should contact Zeba to discuss possible projects.

  • PEOPLE

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    Zeba Wunderlich

    Associate Professor

    PhD, Biophysics, Harvard University

    BA, Molecular Biology & Biochemistry, Statistics, Rutgers University

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    Lianne Cohen

    Post-doctoral Fellow

    PhD, Biology, UCSD

    BS, Biological Sciences, Carnegie Mellon University

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    Jillian Ness

    PhD Student

    BS, Biochemistry, MS, Biology, Purdue University

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    Noshin Nawar

    PhD Student

    BS, Bioengineering, University of Illinois, Urbana-Champaign

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    Julia Gibbs

    PhD Student

    BS, Biological Sciences; BA, English Literature, University of Pittsburgh

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    Emily Yang

    PhD Student

    BA, Cell Biology, Molecular Biology & Genetics, Boston University

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    Emma Rits

    Law Student/Research Assistant

    BA/MS, Cell Biology, Molecular Biology & Genetics; Pure & Applied Mathematics, Boston University

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    Victoria Guarino

    PhD Student

    BS, Biology, University of Massachusetts Amherst

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    Lantz Martin

    Undergraduate Student

    Biochemistry & Molecular Biology

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    Katie Nakai

    Undergraduate Student

    Cellular Biology, Molecular Biology & Genetics

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    Susie Black

    PhD Student

    BA, Biological Sciences, Wellesley College

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    Tamara Hadzic

    PhD Student

    BS, Biochemistry, Northeastern University

  • ALUMNI

    • Christian Mei; Undergraduate/Masters Student, 2022-2025, now a PhD student at Emory University
    • Caitline Sauer; Undergraduate Student, 2023-2025, now a Clinical Research Coordinator at Mass General
    • Yu Wang; Undergraduate Student, 2024
    • Antonio Serrato-Capuchina; Post-doctoral Fellow, 2023-2024, now an Assistant Professor of the Practice at Boston College
    • Sehjin Jo; Undergraduate Student/Lab Assistant, 2023-2024
    • Ishan Ranjan; Master's Student, 2023-2024
    • Francis Vu; Undergraduate Student, 2023-2024, now a student in BU's Biomedical Forensic Sciences program
    • Demi Ring, Undergraduate Student, 2023-2024
    • Jessie Wang; High School Student, Summer 2023
    • Kevin Cabrera, PhD; PhD Student, Developmental and Cell Biology, 2018-2023, now a lab manager/scientist at Dana Farber Cancer Institute
    • Olivia Gibson; Undergraduate Student, 2021-2022
    • Ila Rosen; Undergraduate Student, Cell Biology, Molecular Biology, and Genetics, 2021-2022, now a genomics research assistant at Boston Children's Hospital
    • Bryan Ramirez-Corona, PhD; PhD Student, Developmental and Cell Biology, 2016-2021
    • Rachel Waymack, PhD; PhD Student, Developmental and Cell Biology, 2017-2021, now a research scientist at Sound Agriculture
    • Lily Li, PhD; PhD Student, Developmental and Cell Biology, 2015-2021, now a post-doc at UVA
    • Oluchi Ofoegbu; Undergraduate Student, 2019-2021, now a PhD student at USC
    • Aman Burji; Undergraduate Student, 2020-2021, now a MPH student at UCLA
    • Ariana Lee; Junior Specialist, 2020-2021, now a Master's student at CSU Long Beach
    • Duncan Hoard; Undergraduate Student, 2020-2021
    • Sima Tahmouresie; Undergraduate Student, 2020-2021, now a student at UC Berkeley School of Optometry
    • Vinay Kumar; Research Assistant, 2019-2020
    • Mario Gad; Junior Specialist, 2019-2020, now at UCSF School of Dentistry
    • Phoebe Cao; High School Student, Summer 2019, now an undergraduate at Emory University
    • Stephanie Fruth; Undergraduate Student, Public Health Sciences, 2017-2019, now at Thermo Fisher Scientific
    • Subhapradha Rangarajan; Research Assistant, 2017-2018, now at Western University of Health Sciences
    • Arash Abiri; Undergraduate Student, Biomedical Engineering, 2016-2017, now in UCI MD/PhD program
    • Flo Ramirez; Undergraduate Student, Genetics and Anthropology, 2015-2016, now at the Vincent J Coates Genomics Sequencing Lab at UC Berkeley
    • Punya Narayan; Masters Student, Biotechnology Management, 2016-2017, now at BD Biosciences
    • Marley Hilleger; Masters Student, Developmental and Cell Biology, 2015-2017, now at Eurofins

  • SELECTED PUBLICATIONS

    For an up-to-date and complete list of publications, see Google Scholar.

    K Cabrera, DS Hoard, O Gibson, DI Martinez, Z Wunderlich. PLOS Pathogens. (2023).

    A Fletcher, Z Wunderlich, G Enciso. PLOS Computational Biology. (2023).

    BA Ramirez-Corona, AC Love, S Chandrasekaran, JA Prescher, Z Wunderlich. iScience. (2022).

    BA Ramirez-Corona, SM Fruth, O Ofoegbu, Z Wunderlich. Genome Research. (2021). 

    EZ Kvon, R Waymack, M Gad, Z Wunderlich. Nature Reviews Genetics. (2021).

    F Lopez-Rivera, OK Foster, BJ Vincent, ECG Pym, MDJ Bragdon, J Estrada, AH DePace, Z Wunderlich. G3. (2020).

    L Li, Z Wunderlich. Frontiers in Genetics. (2017).

    Selected older works:

    Z Wunderlich, M DJ Bragdon, BJ Vincent, JA White, J Estrada, AH DePace. Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers. Cell Reports. (2015).

     

    Z Wunderlich, MD Bragdon, K Eckenrode, T Martin, S Pearl, and AH DePace. Dissecting sources of quantitative gene expression pattern divergence between Drosophila species. Molecular Systems Biology. (2012).

     

    Z Wunderlich, AH DePace. Modeling transcriptional networks in Drosophila development at multiple scales. Current Opinion in Genetics and Development. (2011).

     

    Z Wunderlich, LA Mirny. Different gene regulation strategies revealed by analysis of binding motifs. Trends in Genetics. (2009).

     

    Z Wunderlich, LA Mirny. Using genome-wide measurements for computational prediction of SH2-peptide interactions. Nucleic Acids Research. (2009).

     

    Z Wunderlich, LA Mirny. Spatial effects on the speed and reliability of protein-DNA search. Nucleic Acids Research. (2008).

     

    G Kolesov*, Z Wunderlich*, ON Laikova, MS Gelfand, LA Mirny. How gene order is influenced by the biophysics of transcription regulation. PNAS. (2007).

     

    Z Wunderlich and LA Mirny. Using topology of the metabolic network to predict viability of mutant strains. Biophysical Journal. (2006).

  • CONTACT US

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    Email

     

    zeba[at]bu[dot]edu

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    Call

     

    617-353-3833

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    Write

     

    Lab: Room 621

    Office: Room 605B

    610 Commonwealth Ave.

    Boston, MA 02215

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    Visit

     

    Directions to campus are here.

     

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