RESEARCH
Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an a nimal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network's tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically-based computational models to explore questions of gene regulatory network function. We exploit naturally-occuring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.
PEOPLE
Zeba Wunderlich
Assistant Professor
PhD, Harvard University, Biophysics
BA, Molecular Biology & Biochemistry, Statistics, Rutgers University
Bryan Ramirez
PhD Student
BS, Genetics, UC Davis
Kevin Cabrera
PhD Student
BS, Biology, BA Chemistry, Florida International University
Lianne Cohen
Post-doctoral Fellow
PhD, Biology, UCSD
BS, Biological Sciences, Carnegie Mellon University
Jillian Ness
PhD Student
BS, MS, Perdue University
SELECTED PUBLICATIONS
For an up-to-date and complete list of publications, see Google Scholar.
R Waymack, M Gad, Z Wunderlich. bioRxiv. (Pre-print).
L Li, R Waymack, M Gad, Z Wunderlich. bioRxiv. (Pre-print).
BA Ramirez-Corona, SM Fruth, O Ofoegbu, Z Wunderlich. Genome Research. (2021).
EZ Kvon, R Waymack, M Gad, Z Wunderlich. Nature Reviews Genetics. (2021).
F Lopez-Rivera, OK Foster, BJ Vincent, ECG Pym, MDJ Bragdon, J Estrada, AH DePace, Z Wunderlich. G3. (2020).
R Waymack, A Fletcher, G Enciso, Z Wunderlich. eLife. (2020).
Z Wunderlich, CC Fowlkes, KB Eckenrode, MDJ Bragdon, A Abiri, AH DePace. G3. (2019).
L Li, Z Wunderlich. Frontiers in Genetics. (2017).
Z Wunderlich, M DJ Bragdon, BJ Vincent, JA White, J Estrada, AH DePace. Cell Reports. (2015).
Selected older works:
Z Wunderlich, MD Bragdon, K Eckenrode, T Martin, S Pearl, and AH DePace. Dissecting sources of quantitative gene expression pattern divergence between Drosophila species. Molecular Systems Biology. (2012).
Z Wunderlich, AH DePace. Modeling transcriptional networks in Drosophila development at multiple scales. Current Opinion in Genetics and Development. (2011).
Z Wunderlich, LA Mirny. Different gene regulation strategies revealed by analysis of binding motifs. Trends in Genetics. (2009).
Z Wunderlich, LA Mirny. Using genome-wide measurements for computational prediction of SH2-peptide interactions. Nucleic Acids Research. (2009).
Z Wunderlich, LA Mirny. Spatial effects on the speed and reliability of protein-DNA search. Nucleic Acids Research. (2008).
G Kolesov*, Z Wunderlich*, ON Laikova, MS Gelfand, LA Mirny. How gene order is influenced by the biophysics of transcription regulation. PNAS. (2007).
Z Wunderlich and LA Mirny. Using topology of the metabolic network to predict viability of mutant strains. Biophysical Journal. (2006).
CONTACT US
Email
zeba[at]bu[dot]edu
Call
617-353-3833
